The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Nov. 21, 2018
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
David Freeman, Cambridge, MA (US);
Nicholas B. Struntz, Cambridge, MA (US);
Shelby K. Doyle, Cambridge, MA (US);
Andre Richters, Boston, MA (US);
Angela N. Koehler, Belmont, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/06 (2006.01); C07D 495/04 (2006.01); C07D 211/46 (2006.01); A61P 35/00 (2006.01); A61K 31/519 (2006.01); A61K 31/445 (2006.01); A61K 31/4545 (2006.01); A61K 45/06 (2006.01); A61K 31/55 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); A61K 31/445 (2013.01); A61K 31/4545 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 211/46 (2013.01); C07D 401/12 (2013.01); C07D 495/04 (2013.01);
Abstract
Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.