The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Mar. 02, 2020
Pottayil Govindan Nair Sasikumar, Bangalore, IN;
Muralidhara Ramachandra, Bangalore, IN;
Seetharamaiah Setty Sudarshan Naremaddepalli, Bangalore, IN;
Pottayil Govindan Nair Sasikumar, Bangalore, IN;
Muralidhara Ramachandra, Bangalore, IN;
Seetharamaiah Setty Sudarshan Naremaddepalli, Bangalore, IN;
Aurigene Discovery Technologies Limited, Bangalore, IN;
Abstract
The present invention relates to methods of modulating an immune response mediated by a PD-1 signaling pathway and of treating a cancer or an infectious disease. A subject is administered a compound(s) or a pharmaceutically acceptable salt or pharmaceutically acceptable composition thereof of formula (I) In the ring Q is S or O. Rsubstituents are an optionally substituted side chain of the amino acid Ser or Thr and Rsubstituents are a side chain of the amino acids Asn, Asp, Gln, or Glu. Ris hydrogen or —CO-Aaa and Aaa is Thr or Ser with a free, amidated or esterified C-terminus. Rand Rare independently hydrogen or absent. Ris hydrogen, alkyl or acyl.