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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10961187 B1

PDFFull Text
Date of Patent:
Mar. 30, 2021

Filed:

Jun. 17, 2019

Substituted n-acetyl-l-cysteine derivatives and related compounds

Applicant:

Promentis Pharmaceuticals, Inc., Milwaukee, WI (US);

Inventors:

Michael Neary, Milwaukee, WI (US);

James Nieman, Sherwood Park, CA;

Steven Tanis, Carlsbad, CA (US);

Daniel Lawton, Bayside, WI (US);

Garry Smith, Royersford, PA (US);

Assignee:

Promentis Pharmaceuticals, Inc., Milwaukee, WI (US);

Attorney:

Leydig, Voit & Mayer, Ltd.

Primary Examiner:

Mark L Shibuya

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07C 327/34 (2006.01); C07C 323/60 (2006.01); C07D 277/14 (2006.01); C07C 327/26 (2006.01); C07D 277/08 (2006.01); C07C 327/32 (2006.01); C07C 329/06 (2006.01); C07C 323/59 (2006.01); C07C 323/58 (2006.01); C07C 323/57 (2006.01); C07D 241/08 (2006.01); C07D 327/04 (2006.01); A61K 31/265 (2006.01); A61K 31/165 (2006.01); A61K 31/426 (2006.01); A61K 31/513 (2006.01);
U.S. Cl.
CPC ...
C07C 327/34 (2013.01); C07C 323/57 (2013.01); C07C 323/58 (2013.01); C07C 323/59 (2013.01); C07C 323/60 (2013.01); C07C 327/26 (2013.01); C07C 327/32 (2013.01); C07C 329/06 (2013.01); C07D 241/08 (2013.01); C07D 277/08 (2013.01); C07D 277/14 (2013.01); C07D 327/04 (2013.01); A61K 31/165 (2013.01); A61K 31/265 (2013.01); A61K 31/426 (2013.01); A61K 31/513 (2013.01);
Abstract

Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

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