The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Jul. 23, 2015
Newbio Therapeutics, Inc., Shanghai, CN;
Deqiang An, Shanghai, CN;
Nianhe Han, Shanghai, CN;
Di Zeng, Shanghai, CN;
Hang Yang, Shanghai, CN;
Peng Zhu, Shanghai, CN;
Mingzhen Li, Shanghai, CN;
Li Jian, Shanghai, CN;
Chun Yang, Shanghai, CN;
NEWBIO THERAPEUTICS, INC., Shanghai, CN;
Abstract
Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I,L-(T-A-D)  Iwherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.