The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Jun. 16, 2017
Applicants:
Elanco Us Inc., Greenfield, IN (US);
Ambrx, Inc., La Jolla, CA (US);
Inventors:
Peter Connor Canning, Indianapolis, IN (US);
Nickolas Knudsen, Escondido, CA (US);
Lillian Skidmore, San Diego, CA (US);
Assignees:
Elanco US Inc., Greenfield, IN (US);
Ambrx, Inc., La Jolla, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/60 (2017.01); C07K 14/56 (2006.01); A61P 31/14 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 9/0019 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61P 31/14 (2018.01); C07K 14/56 (2013.01); A61K 38/00 (2013.01);
Abstract
Disclosed herein are porcine interferon alpha variants (pIFN-α) comprising a synthetic amino acid at select locations in pIFN-α and a one or two amino acid insertion in the N-terminus after removal of the signal peptide. The pIFN-α variants can further be pegylated. Methods of making and administering these compounds to treat virus infections in pigs and formulations comprising the variants are also provided.