The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
May. 02, 2019
Massachusetts Institute of Technology, Cambridge, MA (US);
Tokitae Llc, Bellevue, WA (US);
Ana Jaklenec, Lexington, MA (US);
William Gates, Redmond, WA (US);
Philip A. Welkhoff, Kirkland, WA (US);
Boris Nikolic, Seattle, WA (US);
Lowell L. Wood, Jr., Bellevue, WA (US);
Robert S. Langer, Newton, MA (US);
Thanh Duc Nguyen, Malden, MA (US);
Stephany Yi Tzeng, Somerville, MA (US);
James J. Norman, North Bethesda, MD (US);
Kevin McHugh, Watertown, MA (US);
TOKITAE LLC, Bellevue, WA (US);
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);
Abstract
Emulsion-based and micromolded ('MM') or three dimensional printed ('3DP') polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.