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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10960049 B1

PDFFull Text
Date of Patent:
Mar. 30, 2021

Filed:

Nov. 14, 2017

Compositions for treating pathological calcification conditions, methods, and host cells using the same

Applicant:

Yale University, New Haven, CT (US);

Inventors:

Demetrios Braddock, Guilford, CT (US);

Ronald Albright, Hamden, CT (US);

Assignee:

Yale University, New Haven, CT (US);

Attorneys:

Saul Ewing Arnstein & Lehr LLP

Kathryn Doyle

Domingos J. Silva

Primary Examiner:

Hope A Robinson

Int. Cl.
CPC ...
A61K 38/17 (2006.01); A01K 67/027 (2006.01); C07K 14/745 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61K 38/46 (2006.01); A61K 38/04 (2006.01); A61K 48/00 (2006.01); C07K 7/06 (2006.01); C12N 9/96 (2006.01); C12N 15/52 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); C12Q 1/6883 (2018.01); A61K 38/02 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1741 (2013.01); A01K 67/0271 (2013.01); A61K 38/02 (2013.01); A61K 38/04 (2013.01); A61K 38/46 (2013.01); A61K 38/465 (2013.01); A61K 48/0058 (2013.01); A61P 9/10 (2018.01); A61P 13/12 (2018.01); C07K 7/06 (2013.01); C07K 14/745 (2013.01); C12N 9/96 (2013.01); C12N 15/52 (2013.01); C12N 15/625 (2013.01); C12N 15/85 (2013.01); C12Q 1/6883 (2013.01); C12Y 301/04001 (2013.01); C12Y 306/01009 (2013.01); A01K 2207/15 (2013.01); A01K 2207/20 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0387 (2013.01); C07K 2319/01 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C07K 2319/33 (2013.01); C07K 2319/70 (2013.01); C12N 2840/007 (2013.01); H05K 999/99 (2013.01);
Abstract

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.

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