The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 2021

Filed:

Dec. 27, 2013
Applicants:

Kyoto Prefectural Public University Corporation, Kyoto, JP;

The Doshisha, Kyoto, JP;

Senju Pharmaceutical Co., Ltd., Osaka, JP;

Inventors:

Noriko Koizumi, Kyotanabe, JP;

Naoki Okumura, Kyotanabe, JP;

Shigeru Kinoshita, Kyoto, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4745 (2006.01); A61K 35/44 (2015.01); A61K 35/30 (2015.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4745 (2013.01); A61K 9/0048 (2013.01); A61K 35/30 (2013.01); A61K 35/44 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention provides an agent for treating or preventing a disease, a disorder or a condition of a corneal endothelium, said agent comprising a corneal endothelial cell and a myosin II-specific inhibitor. More specifically, the myosin II-specific inhibitor is blebbistatin. The disease, the disorder or the condition is typically a disorder associated with Fuchs endothelial corneal dystrophy or corneal endothelial dysfunction (bullous keratopathy). Also provided is a method for treating or preventing a corneal endothelial disease, said method comprising a step of administering an effective amount of a myosin II-specific inhibitor together with a corneal endothelial cell to a subject.


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