The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 2021

Filed:

Feb. 22, 2016
Applicant:

Shanghai Xin Hao Biological Technology Company, Shanghai, CN;

Inventors:

Longfei Zhang, Shanghai, CN;

Pengfei Wang, Shanghai, CN;

Zhongjun Ma, Shanghai, CN;

Huanzhang Zhu, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/23 (2006.01); A61K 31/357 (2006.01); C07D 317/72 (2006.01); C07D 493/10 (2006.01); C07C 67/28 (2006.01); C07C 67/48 (2006.01); C07C 69/33 (2006.01); A61P 31/18 (2006.01);
U.S. Cl.
CPC ...
A61K 31/23 (2013.01); A61K 31/357 (2013.01); A61P 31/18 (2018.01); C07C 67/28 (2013.01); C07C 67/48 (2013.01); C07C 69/33 (2013.01); C07D 317/72 (2013.01); C07D 493/10 (2013.01);
Abstract

Provided in the present invention are ingenol compounds and a use thereof in preparing an anti-HIV latency drug. In particular, provided in the present invention is a use of ingenol compounds and pharmaceutically acceptable salts thereof for preparing a drug for: (a) intervening with HIV viral latency; (b) activating an HIV virus that has been integrated into mammalian genomes; and/or (c) inducing the expression of the dormant HIV provirus in infected cells. The compounds of the present invention may also be used in combination with antiretroviral drugs to accelerate the removal of latent viral reservoirs.


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