The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 2021

Filed:

May. 12, 2015
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Fady Dawoud, Baltimore, MD (US);

Karl H. Schuleri, Baltimore, MD (US);

Amir Pourmorteza, Baltimore, MD (US);

Albert C. Lardo, Baldwin, MD (US);

Elliot McVeigh, Timonium, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); A61B 34/10 (2016.01); A61B 5/0452 (2006.01); A61B 5/0536 (2021.01); A61N 1/05 (2006.01); A61N 1/362 (2006.01); A61B 5/0408 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0035 (2013.01); A61B 5/0452 (2013.01); A61B 5/0536 (2013.01); A61B 5/7203 (2013.01); A61B 5/743 (2013.01); A61B 6/032 (2013.01); A61B 6/4417 (2013.01); A61B 6/503 (2013.01); A61B 6/5247 (2013.01); A61B 34/10 (2016.02); A61N 1/0587 (2013.01); A61N 1/3627 (2013.01); A61B 5/04085 (2013.01); A61B 6/5217 (2013.01); A61B 2576/023 (2013.01);
Abstract

The present invention is directed to a method for combining assessment of different factors of dyssynchrony into a comprehensive, non-invasive toolbox for treating patients with a CRT therapy device. The toolbox provides high spatial resolution, enabling assessment of regional function, as well as enabling derivation of global metrics to improve patient response and selection for CRT therapy. The method allows for quantitative assessment and estimation of mechanical contraction patterns, tissue viability, and venous anatomy from CT scans combined with electrical activation patterns from Body Surface Potential Mapping (BSPM). This multi-modal method is therefore capable of integrating electrical, mechanical, and structural information about cardiac structure and function in order to guide lead placement of CRT therapy devices. The method generates regional electro-mechanical properties overlaid with cardiac venous distribution and scar tissue. The fusion algorithm for combining all of the data suggests cardiac segments and routes for implantation of epicardial pacing leads.


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