The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Aug. 24, 2018
Case Western Reserve University, Cleveland, OH (US);
Anant Madabhushi, Shaker Heights, OH (US);
Xiangxue Wang, Cleveland Heights, OH (US);
Vamsidhar Velcheti, Pepper Pike, OH (US);
Case Western Reserve University, Cleveland, OH (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Abstract
Embodiments predict early stage NSCLC recurrence, and include an image acquisition circuit configured to access an image of a region of tissue demonstrating early-stage NSCLC including a plurality of cellular nuclei; a nuclei detecting and segmentation circuit configured to detect a member of the plurality; and classify the member as a tumor infiltrating lymphocyte (TIL) nucleus or non-TIL nucleus; a spatial TIL feature circuit configured to extract spatial TIL features from the plurality, the spatial TIL features including a first subset of features based on the spatial arrangement of TIL nuclei, and a second subset of features based on the spatial relationship between TIL nuclei and non-TIL nuclei; and an NSCLC recurrence classification circuit configured to compute a probability that region will experience recurrence based on the spatial TIL features; and generate a classification of the region as likely or unlikely to experience recurrence based on the probability.