The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Jan. 17, 2019
Applicant:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Inventors:
Uma Sinha, San Francisco, CA (US);
Genmin Lu, Burlingame, CA (US);
Pamela B. Conley, Palo Alto, CA (US);
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/48 (2006.01); C12N 9/64 (2006.01); A61K 47/60 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6432 (2013.01); A61K 38/482 (2013.01); A61K 38/4826 (2013.01); A61K 38/4833 (2013.01); A61K 38/4846 (2013.01); A61K 38/4853 (2013.01); A61K 47/60 (2017.08); C12Y 304/21006 (2013.01); A61K 39/00 (2013.01);
Abstract
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.