The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Oct. 21, 2016
Applicant:
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Inventor:
Rupesh Amin, Seattle, WA (US);
Assignee:
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C12N 9/52 (2006.01); C12N 9/50 (2006.01); C12N 15/70 (2006.01); C07K 16/44 (2006.01); C07K 14/705 (2006.01); C12N 9/64 (2006.01); C07K 16/00 (2006.01); C12N 9/96 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); C07K 14/705 (2013.01); C07K 16/005 (2013.01); C07K 16/44 (2013.01); C07K 16/468 (2013.01); C12N 9/50 (2013.01); C12N 9/6472 (2013.01); C12N 9/96 (2013.01); C07K 2317/22 (2013.01); C07K 2317/32 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/61 (2013.01); C07K 2319/70 (2013.01); C07K 2319/71 (2013.01); C07K 2319/715 (2013.01); C07K 2319/80 (2013.01);
Abstract
Methods to create chemically-induced dimerizing (CID) protein systems and uses thereof are described. The methods utilize antibody binding domain dimerizing proteins. The created systems can be used to regulate cellular events such as gene expression, receptor signaling and cell death to effectuate a variety of clinically relevant treatment outcomes.