The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Sep. 29, 2017
The Regents of the University of California, Oakland, CA (US);
Stephen L. Nishimura, San Francisco, CA (US);
Jianlong Lou, San Francisco, CA (US);
James D. Marks, San Francisco, CA (US);
Jody L. Baron, San Francisco, CA (US);
Yifan Cheng, San Francisco, CA (US);
Shenping Wu, San Francisco, CA (US);
Anthony Cormier, San Francisco, CA (US);
Naoki Takasaka, San Francisco, CA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Abstract
Provided is an antibody that specifically binds human αvββ and blocks binding of TGFp peptide to αvβ8, wherein the antibody binds to the specificity determining loop (SDL) of human β8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the al helix of human β8, or the al helix of human β8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-αvββ antibodies or antigen-binding molecules thereof.