The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
May. 24, 2017
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Institut Pasteur DE Lille, Lille, FR;
Université DE Lille 1 Sciences ET Technologies, Villeneuve d'Ascq, FR;
Université DE Droit ET DE LA Santé DE Lille 2, Lille, FR;
INSERM (Institut National de la Santé et de la Recherche Médicale), Paris, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Institut Paseur de Lille, Lille, FR;
Universitéde Lille, Lille, FR;
Abstract
The present invention relates to methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections. The increasing burden of antimicrobial resistance coupled with the decreasing number of antibiotics in development has urged for strategies to elaborate new therapies. The inventors showed a therapeutic effect of IL-20 receptor 10 antagonists in pulmonary bacterial infection mouse model. Indeed, they demonstrated that treatment with IL-20 receptor antagonists reduces bacterial burden, cellular infiltration and inflammation in bronchoalveolar lavage fluid (BALF) and lung. In particular, the present invention relates to an antagonist of IL-20 cytokines, or/and an antagonist of IL-20RB receptor for use in a method for the treatment of pulmonary bacterial infections in a subject in 15 need thereof.