The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Sep. 06, 2019
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Jun O. Liu, Clarksville, MD (US);
Jingxin Wang, Baltimore, MD (US);
Zufeng Guo, Baltimore, MD (US);
Wei Li, Xiangtan, CN;
Shridhar Bhat, Cockeysville, MD (US);
Manisha Das, Centreville, VA (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); C07K 17/08 (2006.01); G01N 33/566 (2006.01); A61K 31/436 (2006.01); A61K 31/4353 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); C07D 498/14 (2006.01); C07D 515/04 (2006.01); C07D 515/14 (2006.01);
U.S. Cl.
CPC ...
C07K 7/645 (2013.01); A61K 31/436 (2013.01); A61K 31/4353 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 498/14 (2013.01); C07D 515/04 (2013.01); C07D 515/14 (2013.01); C07K 17/08 (2013.01); G01N 33/566 (2013.01);
Abstract
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.