The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Jun. 29, 2017
National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD (US);
Vanderbilt University, Nashville, TN (US);
The Uab Research Foundation, Birmingham, AL (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
David J. Maloney, Points of Rocks, MD (US);
Alex Gregory Waterson, Nashville, TN (US);
Ganesha Rai Bantukallu, Arlington, VA (US);
Kyle Ryan Brimacombe, Brook Park, OH (US);
Plamen Christov, Mount Juliet, TN (US);
Chi V. Dang, Penn Valley, PA (US);
Victor M. Darley-Usmar, Birmingham, AL (US);
Matthew Hall, Darnestown, MD (US);
Xin Hu, Frederick, MD (US);
Ajit Jadhav, Chantilly, VA (US);
Somnath Jana, Nashville, TN (US);
Kwangho Kim, Nashville, TN (US);
William J. Moore, Hagerstown, MD (US);
Bryan T. Mott, College Park, MD (US);
Leonard M. Neckers, Bethesda, MD (US);
Anton Simeonov, Bethesda, MD (US);
Gary Allen Sulikowski, Brentwood, TN (US);
Daniel Jason Urban, Poolesville, MD (US);
Shyh Ming Yang, Doylestown, PA (US);
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
THE UAB RESEARCH FOUNDATION, Birmingham, AL (US);
VANDERBILT UNIVERSITY, Nashville, TN (US);
NATIONAL INSTITUTES OF HEALTH, UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US);
Abstract
The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R, R, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.