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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10954223 B1

PDFFull Text
Date of Patent:
Mar. 23, 2021

Filed:

Jan. 08, 2019

Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof

Applicant:

Hangzhou Solipharma Co., Ltd., Zhejiang, CN;

Inventors:

Xiaoxia Sheng, Zhejiang, CN;

Xiaohong Sheng, Zhejiang, CN;

Kun Zhao, Zhejiang, CN;

Xiaoye Song, Zhejiang, CN;

Assignee:

Hangzhou SoliPharma Co., Ltd., Hangzhou, CN;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

John S Kenyon

Int. Cl.
CPC ...
C07D 409/10 (2006.01); A61K 31/7042 (2006.01); A61K 9/00 (2006.01); A61K 9/10 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61K 9/48 (2006.01); A61K 31/381 (2006.01); A61K 47/12 (2006.01); A61K 47/14 (2017.01); A61K 47/36 (2006.01);
U.S. Cl.
CPC ...
C07D 409/10 (2013.01); A61K 9/0053 (2013.01); A61K 9/0095 (2013.01); A61K 9/10 (2013.01); A61K 9/1623 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/2813 (2013.01); A61K 9/2853 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 31/381 (2013.01); A61K 31/7042 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/36 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention relates to canagliflozin Monohydrate and its crystalline forms, which as compared to the prior art, have higher stability in water or aqueous system, are more suitable for wet granulation processes or suspension preparations and have good storage stability; the present invention also relates to preparation methods of canagliflozin Monohydrate and its crystalline forms, pharmaceutical compositions thereof and uses thereof in preparation of drugs for treating diseases such as diabetes, diabetes complications, obesity and so on.

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