The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2021
Filed:
Dec. 26, 2017
Riken, Saitama, JP;
The University of Tokyo, Tokyo, JP;
Yoshinobu Hashizume, Saitama, JP;
Katsuhiko Sekimata, Saitama, JP;
Hirokazu Kubota, Saitama, JP;
Hirofumi Yamamoto, Saitama, JP;
Yasuko Koda, Saitama, JP;
Hiroo Koyama, Saitama, JP;
Tomonori Taguri, Saitama, JP;
Tomohiro Sato, Saitama, JP;
Akiko Tanaka, Saitama, JP;
Kohei Miyazono, Tokyo, JP;
RIKEN, Saitama, JP;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Abstract
The present invention relates to novel and excellent small-molecule-compounds that specifically antagonize BMP signal pathways, and these compounds can be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus can be used to treat diseases or pathological symptoms related to BMP signal pathway including inflammation, cardiovascular diseases, hematopoietic diseases, cancer, osteodystrophia, or the like, particularly, fibrodysplasia ossificans progressiva, and the present invention relates to provision of a pharmaceutical and pharmacological agent used for specifically antagonizing the BMP signal pathways and acting on the BMP signal pathways in the prevention and treatment or experimental application since the compounds can be beneficial for regulating cell differentiation and/or cell proliferation.