The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jun. 16, 2020
Applicants:
Yi Xiao, Miami, FL (US);
Yingping Luo, Miami, FL (US);
Haixiang Yu, Miami, FL (US);
Inventors:
Assignee:
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, Miami, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); C12Q 1/6883 (2018.01); G01N 33/94 (2006.01); G01N 33/52 (2006.01);
U.S. Cl.
CPC ...
G01N 33/9486 (2013.01); G01N 33/52 (2013.01);
Abstract
The subject invention provides methods, assays, and products for visual detection of small-molecule targets in a sample in both clinical and field settings within minutes. The subject invention is based on an aptamer sensor that reports the presence of small-molecule target via a sensitive colorimetric signal for naked-eye detection. The aptamer sensor is a CBSAzyme-based sensor having both target-mediated cooperative behavior of the CBSA and peroxidase-mimicking catalytic activity of DNAzyme. The subject invention also provides methods of using the CBSAzyme-based sensor.