logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10947598 B1

PDFFull Text
Date of Patent:
Mar. 16, 2021

Filed:

Sep. 29, 2016

Methods for determining the metabolic status of lymphomas

Applicants:

Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;

Universite Nice Sophia Antipolis, Nice, FR;

Assistance Publique-hopitaux DE Paris (Aphp), Paris, FR;

Inventors:

Jean-Ehrland Ricci, Nice, FR;

Johanna Chiche, Nice, FR;

Catherine Thieblemont, Paris, FR;

Assignees:

INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris, FR;

Université Côte d'Azur, Nice, FR;

ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP), Paris, FR;

Attorney:

W&C IP

Primary Examiner:

Lisa V Cook

Int. Cl.
CPC ...
G01N 31/00 (2006.01); G01N 33/53 (2006.01); C12Q 1/6886 (2018.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01); A61K 38/50 (2006.01); A61K 31/436 (2006.01); A61K 31/155 (2006.01); A61P 35/00 (2006.01); G01N 33/574 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/155 (2013.01); A61K 31/436 (2013.01); A61K 38/50 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01); C07K 16/2887 (2013.01); C07K 16/30 (2013.01); C12Y 102/01012 (2013.01); C12Y 305/01001 (2013.01); G01N 33/57407 (2013.01); C07K 2317/24 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/904 (2013.01); G01N 2333/90203 (2013.01); G01N 2800/52 (2013.01);
Abstract

Provided is an in vitro method for determining the metabolic status of a lymphoma comprising a step of determining the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in lymphoma cells, wherein a low level of GAPDH expression is indicative of oxidative phosphorylation (OXPHOS) status. Also provided is an in vitro method for predicting the responsiveness of a patient afflicted with a lymphoma to a treatment with a metabolic inhibitor selected from the group consisting of mitochondrial metabolic inhibitors and glutamine metabolism inhibitors comprising a step of determining the level of GAPDH expression in lymphoma cells obtained from said patient, wherein a low level of GAPDH expression is predictive of a response to a treatment with a metabolic inhibitor.

Find Patent Forward Citations

Ricci, Jean-Ehrland. (2021). Methods for determining the metabolic status of lymphomas (U.S. Patent No. 10947598). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10947598

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…