The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Mar. 28, 2016
Applicant:
Cytomx Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Sherry Lynn La Porte, San Francisco, CA (US);
Stephen James Moore, Danville, CA (US);
James William West, Bend, OR (US);
Assignee:
CytomX Therapeutics, Inc., South San Francisco, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12Q 1/37 (2006.01); G01N 33/68 (2006.01); C07K 14/00 (2006.01); C07K 16/18 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C40B 40/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C07K 14/001 (2013.01); C07K 14/705 (2013.01); C07K 16/18 (2013.01); C07K 16/2809 (2013.01); C07K 16/2866 (2013.01); C12N 15/1044 (2013.01); C12Q 1/37 (2013.01); G01N 33/6845 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/21 (2013.01); C40B 40/02 (2013.01);
Abstract
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.