The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 16, 2021

Filed:

Feb. 20, 2019
Applicant:

Roche Sequencing Solutions, Inc., Pleasanton, CA (US);

Inventors:

Aruna Ayer, Santa Clara, CA (US);

Arkadiusz Bibillo, Cupertino, CA (US);

Preethi Sarvabhowman, Santa Clara, CA (US);

Dhruti Vasudev Dalal, Sunnyvale, CA (US);

Ilya Lederman, San Francisco, CA (US);

Eileen Thai, San Jose, CA (US);

Assignee:

Roche Sequencing Solutions, Inc., Pleasanton, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1252 (2013.01); C12Y 207/07007 (2013.01);
Abstract

Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.


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