The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jun. 15, 2018
Development Center for Biotechnology, New Taipei, TW;
Chao-Pin Lee, New Taipei, TW;
Shih-Hsien Chuang, New Taipei, TW;
Chuan-Lung Hsu, New Taipei, TW;
Yi-Jen Chen, New Taipei, TW;
Yu-Chin Nieh, New Taipei, TW;
Win-Yin Wei, New Taipei, TW;
Chia-Cheng Wu, New Taipei, TW;
Development Center for Biotechnology, New Taipei, TW;
Abstract
An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D), wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.