The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Feb. 22, 2019
Applicant:
Immundiagnostik Ag, Bensheim, DE;
Inventors:
Franz Paul Armbruster, Bensheim, DE;
Berthold Hocher, Berlin, DE;
Assignee:
Immundiagnostik AG, Bensheim, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); A61M 1/34 (2006.01); A61K 35/14 (2015.01); A61K 35/16 (2015.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 35/14 (2013.01); A61K 35/16 (2013.01); A61M 1/3486 (2014.02); A61M 1/3496 (2013.01); C07K 16/24 (2013.01); G01N 33/6893 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); G01N 2333/47 (2013.01); G01N 2800/323 (2013.01); G01N 2800/347 (2013.01);
Abstract
A novel therapy concept based on a removal of circulating BSP (bone sialoprotein) from the plasma of patients with chronic kidney disease (CKD) or highly at risk of developing arterial and vascular calcifications. The method comprises method of treatment of extracellular tissue and vascular calcifications, atherosclerosis, arteriosclerosis, and arterial calcification. The beneficial effects of this therapy have been proven by the observed correspondence between levels of circulating free BSP levels and mortality of CKD patients as well as in animal models.