The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Aug. 08, 2014
Applicant:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Inventors:
Lily Zhu, Belmont, MA (US);
Anxhela Kole, Quincy, MA (US);
John Kulman, Belmont, MA (US);
Marisol Acosta, Worcester, MA (US);
Assignee:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/36 (2006.01); C07K 14/755 (2006.01);
U.S. Cl.
CPC ...
C07K 1/36 (2013.01); C07K 14/755 (2013.01); C07K 2319/31 (2013.01);
Abstract
The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.