The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jun. 28, 2019
Applicant:
University of Puerto Rico, San Juan, PR (US);
Inventors:
Cornelis P. Vlaar, San Juan, PR (US);
Suranganie Dharmawardhane Flanagan, San Juan, PR (US);
Eliud Hernandez-O'Farrill, San Juan, PR (US);
Linette Castillo-Pichardo, San Juan, PR (US);
Assignee:
University of Puerto Rico, San Juan, PR (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 491/048 (2006.01); C07D 403/04 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01);
Abstract
Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.