The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Aug. 07, 2018
Applicant:
Duquesne University of the Holy Spirit, Pittsburgh, PA (US);
Inventor:
Aleem Gangjee, Allison Park, PA (US);
Assignee:
Duquesne University of the Holy Spirit, Pittsburgh, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 491/048 (2006.01); C07D 239/70 (2006.01); A61K 31/517 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); A61K 31/517 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07D 239/70 (2013.01); C07D 487/04 (2013.01);
Abstract
The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of Formula III, and Formula IV, and pharmaceutically acceptable salts, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds and pharmaceutical compositions for treating tumor cells and inhibiting mitosis of cancerous cells.