The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Aug. 30, 2019
Applicant:
Rhizen Pharmaceuticals SA, La Chaux-de-Fonds, CH;
Inventor:
Swaroop K. Vakkalanka, La Chaux-de-Fonds, CH;
Assignee:
RHIZEN PHARMACEUTICALS SA, La Chaux-de-Fonds, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 487/04 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); C07C 309/30 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07C 309/30 (2013.01); C07B 2200/13 (2013.01); Y02A 50/30 (2018.01);
Abstract
The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one (TGR-1202). The present invention also relates to methods of preparing the same, pharmaceutical compositions containing them, and methods of treating a PI3K kinase mediated disease or disorder, such as cancer, by administering the same.