The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Sep. 28, 2017
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Paul Wender, Stanford, CA (US);
Ryan Quiroz, Boston, MA (US);
Stephen Ho, Stanford, CA (US);
Akira Shimizu, Stanford, CA (US);
Steven Ryckbosch, Albany, CA (US);
Matthew C. Stevens, Atherton, CA (US);
Matthew S. Jeffreys, King of Prussia, PA (US);
Clayton Hardman, Stanford, CA (US);
Jack Sloane, Stanford, CA (US);
The Board of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.