The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 16, 2021

Filed:

Sep. 25, 2018
Applicant:

Dong-a Socio Holdings Co., Ltd., Seoul, KR;

Inventors:

Myeong-Seop Kim, Gyeonggi-do, KR;

Sumin Kim, Seoul, KR;

Jin Kwan Kim, Gyeonggi-do, KR;

Hadong Kim, Seoul, KR;

Ki Moon Ryu, Gyeonggi-do, KR;

Seong Jin Park, Seoul, KR;

Taesun Park, Gyeonggi-do, KR;

Joon-Ho Sheen, Seoul, KR;

Taeyoung Yoon, Seoul, KR;

Mi Yeon Jang, Gyeonggi-do, KR;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 213/82 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 213/82 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention provides heterocyclic compounds, the stereoisomer thereof, the enantiomer thereof, or the pharmaceutically acceptable salt, which are capable of modulating the activity of Mer receptor tyrosine kinase (MERTK). This invention also provides pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The present invention is directed to MERTK inhibitory compounds with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to MERTK dysregulation.


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