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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10947205 B1

PDFFull Text
Date of Patent:
Mar. 16, 2021

Filed:

Apr. 29, 2019

Oxazolidinone compounds and methods of use thereof as antibacterial agents

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Mihir B. Mandal, Westfield, NJ (US);

David B. Olsen, Lansdale, PA (US);

Jing Su, Scotch Plains, NJ (US);

Lihu Yang, Edison, NJ (US);

Katherine Young, Metuchen, NJ (US);

Takao Suzuki, Shanghai, CN;

Lanying You, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Janet E. Fair

Catherine D. Fitch

Primary Examiner:

Matthew P Coughlin

Assistant Examiner:

Sagar Patel

Int. Cl.
CPC ...
A61K 31/422 (2006.01); A61K 31/541 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 417/10 (2006.01); C07D 413/10 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 263/20 (2006.01); A61K 31/421 (2006.01); A61K 45/06 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); C07D 413/06 (2006.01); A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/553 (2006.01); C07D 413/04 (2006.01);
U.S. Cl.
CPC ...
C07D 263/20 (2013.01); A61K 31/421 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and Rare as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections bycomprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

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