The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Sep. 26, 2019
Xi'an Jiaotong University, Xi'an, CN;
Jian-Kang Liu, Xi'an, CN;
Xu-Yun Liu, Xi'an, CN;
Ya-Chong Hu, Xi'an, CN;
Lin Zhao, Xi'an, CN;
Yong-Yao Wang, Xi'an, CN;
Cai-Yue Zhu, Xi'an, CN;
Zhen Wang, Xi'an, CN;
Jing Lou, Xi'an, CN;
Qing-Qing Ma, Xi'an, CN;
Yu-Xia Zhang, Xi'an, CN;
Qing-Lin Jiang, Xi'an, CN;
Xiao-Hong Xu, Xi'an, CN;
Ting-Hua Zhang, Xi'an, CN;
Jian-Gang Long, Xi'an, CN;
XI'AN JIAOTONG UNIVERSITY, Xi'an, CN;
Abstract
The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I.