The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Sep. 01, 2016
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
University of Rijeka Faculty of Medicine, Rijeka, HR;
Inventors:
Ofer Mandelboim, Shoham, IL;
Noa S. Kaynan, Kibbutz Barkai, IL;
Pinchas Tsukerman, Jerusalem, IL;
Stipan Jonjic, Viskovo, HR;
Assignees:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
University of Rijeka Faculty of Medicine, Rijeka, HR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); G01N 33/577 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61P 35/00 (2018.01); C07K 16/28 (2013.01); C07K 16/2803 (2013.01); G01N 33/577 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions including them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.