The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jun. 27, 2018
Vib Vzw, Ghent, BE;
Universiteit Gent, Ghent, BE;
Centre National DE LA Recherche Scientifique, Paris, FR;
Université DE Montpellier, Montpellier, FR;
Centre Hospitalier Regional Universitaire DE Montpellier, Montpellier, FR;
Universitat Osnabruck, Osnabrück, DE;
Jan Tavernier, Balegem, BE;
Gilles Uzé, Montpellier, FR;
Guillaume Cartron, Combaillaux, FR;
Franciane Paul, Montpellier, FR;
Jacob Piehler, Osnabrück, DE;
VIB VZW, Ghent, BE;
UNIVERSITEIT GENT, Ghent, BE;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
UNIVERSITÉ DE MONTPELLIER, Montpellier, FR;
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER, Montpellier, FR;
UNIVERSITAT OSNABRUCK, Osnabrück, DE;
Abstract
This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified α-helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified α-helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.