The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
May. 01, 2018
Applicant:
United Therapeutics Corporation, Silver Spring, MD (US);
Inventors:
Sarah Hogan, Raleigh, NC (US);
Roger Marquez Ilagan, Durham, NC (US);
Maria Pia Rodriguez, Durham, NC (US);
Carolina Medrano, Durham, NC (US);
John Cheadle, Durham, NC (US);
Assignee:
United Therapeutics Corporation, Silver Spring, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/14 (2006.01); A61K 35/28 (2015.01); A61P 9/12 (2006.01); C12N 9/12 (2006.01); C12N 5/0775 (2010.01); C07K 14/47 (2006.01); A61K 31/519 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 31/519 (2013.01); A61P 9/12 (2018.01); C07K 14/47 (2013.01); C12N 5/0662 (2013.01); C12N 5/0669 (2013.01); C12N 5/0691 (2013.01); C12N 9/1205 (2013.01); C12N 9/14 (2013.01); C12Y 207/0104 (2013.01); C12Y 306/01003 (2013.01); A61K 48/00 (2013.01); C12N 2310/141 (2013.01); C12N 2502/1394 (2013.01);
Abstract
Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.