The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jul. 31, 2017
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Jeremy E. Wilusz, Philadelphia, PA (US);
Phillip A. Sharp, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); C12N 15/113 (2010.01); C12N 15/67 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 48/00 (2013.01); C12N 15/113 (2013.01); C12N 15/67 (2013.01); C12N 2310/15 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/52 (2013.01);
Abstract
The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a stabilizing triple helical structure. Related methods for expressing RNA in vivo and in vitro are also disclosed.