The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jun. 18, 2019
Applicant:
Epizyme, Inc., Cambridge, MA (US);
Inventor:
Heike Keilhack, Belmont, MA (US);
Assignee:
Epizyme, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 45/06 (2006.01); A61K 31/45 (2006.01); A61K 31/453 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61K 31/5375 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/45 (2013.01); A61K 31/453 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); A61K 31/5375 (2013.01);
Abstract
The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.