The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
Jul. 29, 2011
Applicants:
Said M. Sebti, Tampa, FL (US);
Andrew D. Hamilton, Oxford, GB;
Inventors:
Said M. Sebti, Tampa, FL (US);
Andrew D. Hamilton, Oxford, GB;
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
A61K 31/496 (2013.01);
Abstract
Methods of inducing tumor regression, inhibiting tumor growth, and inducing apoptosis with selective peptidomimetic inhibitors of geranylgeranyltransferase I (GGTase I), are provided. In one aspect, GGTI-2418 and its methylester GGTI-2417, increase levels of the cyclin-dependent kinase (Cdk) inhibitor p27and induce breast tumor regression in vivo. In another aspect, GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27at Thr187 and accumulates p27in the nucleus.