The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2021
Filed:
May. 31, 2019
Applicant:
Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, CN;
Inventors:
Yuelei Shen, Beijing, CN;
Yang Bai, Beijing, CN;
Yanan Guo, Beijing, CN;
Rui Huang, Beijing, CN;
Xiaofei Zhou, Beijing, CN;
Chaoshe Guo, Beijing, CN;
Assignee:
Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C07H 21/04 (2006.01); C07K 14/705 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 14/70532 (2013.01); C12N 15/907 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01);
Abstract
This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) programmed death-ligand 1 (PD-L1, PDL1, or B7-H1), and methods of use thereof. In one aspect, the disclosure relates to genetically-modified, non-human animals whose genome comprises at least one chromosome comprising a sequence encoding a human or chimeric programmed death-ligand 1 (PD-L1).