The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2021
Filed:
Sep. 18, 2019
Applicant:
Immunogen, Inc., Waltham, MA (US);
Inventors:
Wayne C. Widdison, Belmont, MA (US);
Robert Yongxin Zhao, Lexington, MA (US);
Assignee:
IMMUNOGEN, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/16 (2006.01); C07D 498/18 (2006.01); H01R 12/58 (2011.01); H05K 1/02 (2006.01); H05K 1/11 (2006.01); H05K 1/18 (2006.01);
U.S. Cl.
CPC ...
H01R 12/585 (2013.01); C07D 498/16 (2013.01); C07D 498/18 (2013.01); H05K 1/0203 (2013.01); H05K 1/116 (2013.01); H05K 1/181 (2013.01);
Abstract
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.