The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 09, 2021

Filed:

Nov. 13, 2012
Applicant:

Koninklijke Philips N.v., Eindhoven, NL;

Inventors:

Toon Hendrik Evers, Eindhoven, NL;

Maatje Koets, Wageningen, NL;

Assignee:

Koninklijke Philips N.V., Eindhoven, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); G01N 21/00 (2006.01); G01N 33/68 (2006.01); G01N 33/553 (2006.01); G01N 33/74 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54393 (2013.01); G01N 21/00 (2013.01); G01N 33/54326 (2013.01); G01N 33/54353 (2013.01); G01N 33/54366 (2013.01); G01N 33/553 (2013.01); G01N 33/6887 (2013.01); G01N 33/74 (2013.01); G01N 2333/58 (2013.01);
Abstract

A device detects a target molecule in a sample in a sample container to measure the target molecule. A first particle is functionalized with a first binding molecule capable of specifically binding to said target molecule. A surface structure includes a second binding molecule. The surface structure covers a flat sensor or is present on a second particle. The first particle is capable of binding the second binding molecule of the surface structure directly or indirectly. The first and/or second binding molecule is indirectly attached to the particle surface of the first and/or second particle and/or the flat sensor surface via a long and rigid linker molecule. A length and a consistency of the linker molecule is selected such as to result in an average extension length of the linker of more than 60 nm. A number of particle clusters or of bound particles is directly or inversely related to an amount of the target molecules present in the sample.


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