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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10941129 B1

PDFFull Text
Date of Patent:
Mar. 09, 2021

Filed:

May. 23, 2017

Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof

Applicants:

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, CN;

Tianjin Chase Sun Pharmaceutical Co., Ltd, Tianjin, CN;

Inventors:

Zhiqiang Feng, Beijing, CN;

Xiaoguang Chen, Beijing, CN;

Yang Yang, Beijing, CN;

Fangfang Lai, Beijing, CN;

Ming Ji, Beijing, CN;

Lijing Zhang, Beijing, CN;

Yi Zheng, Beijing, CN;

Nina Xue, Beijing, CN;

Ke Wang, Beijing, CN;

Ling Li, Beijing, CN;

Assignees:

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, CN;

Tianjin Chase Sun Pharmaceutical Co., LTD, Tianjin, CN;

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
C07D 295/155 (2006.01); C07C 233/36 (2006.01); C07C 255/54 (2006.01); C07D 405/12 (2006.01); C07C 311/05 (2006.01); C07D 319/18 (2006.01); C07D 207/16 (2006.01); C07C 45/61 (2006.01); C07C 231/12 (2006.01); C07D 401/14 (2006.01); A61P 35/00 (2006.01); C07C 211/29 (2006.01); C07C 229/36 (2006.01); C07C 235/34 (2006.01); C07D 221/00 (2006.01); C07D 265/30 (2006.01); C07D 407/12 (2006.01); C07D 269/02 (2006.01); C07C 271/64 (2006.01); C07C 227/12 (2006.01); C07C 269/02 (2006.01); C07D 207/08 (2006.01); C07D 309/14 (2006.01); C07D 319/16 (2006.01); A61K 31/36 (2006.01); A61K 31/165 (2006.01); A61K 31/277 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 295/155 (2013.01); A61P 35/00 (2018.01); C07C 45/61 (2013.01); C07C 211/29 (2013.01); C07C 227/12 (2013.01); C07C 229/36 (2013.01); C07C 231/12 (2013.01); C07C 233/36 (2013.01); C07C 235/34 (2013.01); C07C 255/54 (2013.01); C07C 269/02 (2013.01); C07C 271/64 (2013.01); C07C 311/05 (2013.01); C07D 207/08 (2013.01); C07D 207/16 (2013.01); C07D 221/00 (2013.01); C07D 265/30 (2013.01); C07D 309/14 (2013.01); C07D 319/16 (2013.01); C07D 319/18 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); A61K 31/165 (2013.01); A61K 31/277 (2013.01); A61K 31/36 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention discloses a benzyl phenyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to benzyl phenyl ether derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

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