The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2021
Filed:
Jul. 28, 2015
Technische Universitaet Dresden, Dresden, DE;
Michael Schroeder, Dresden, DE;
Yixin Zhang, Dresden, DE;
Joerg-Christian Heinrich, Dresden, DE;
Joachim Haupt, Bobritzsch-Hilbersdorf, DE;
Sainitin Donakonda, Andhra Pradesh, IN;
Petra Lennig, Dresden, DE;
Technische Universitaet Dresden, Dresden, DE;
Abstract
The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.