The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2021
Filed:
Oct. 16, 2019
Applicant:
Shy Therapeutics Llc, Harrison, NY (US);
Inventors:
Yaron R. Hadari, Harrison, NY (US);
Luca Carta, Hartsdale, NY (US);
Michael Schmertzler, St. Petersburg, FL (US);
Theresa M. Williams, Harleysville, PA (US);
Charles H. Reynolds, Austin, TX (US);
Rebecca Hutcheson, Lake Peekskill, NY (US);
Assignee:
Shy Therapeutics LLC, Harrison, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4365 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 25/28 (2006.01); C07D 495/04 (2006.01); A61K 31/505 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4365 (2013.01); A61K 31/505 (2013.01); A61P 25/28 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07D 495/04 (2013.01); C12N 15/1037 (2013.01); C12N 15/1065 (2013.01);
Abstract
Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.