The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 02, 2021

Filed:

Dec. 27, 2014
Applicants:

Bonac Corporation, Kurume, JP;

Tokyo Medical University, Tokyo, JP;

Inventors:

Masahiko Kuroda, Tokyo, JP;

Shinichiro Ohno, Tokyo, JP;

Eriko Aoki, Kurume, JP;

Yasuhiko Yoshida, Kurume, JP;

Shiori Kato, Kurume, JP;

Tadaaki Ohgi, Kurume, JP;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); C12N 2310/141 (2013.01); C12N 2310/318 (2013.01); C12N 2310/531 (2013.01);
Abstract

The invention provides an artificial match-type miRNA utilizing miRNA. In particular, the invention provides a single strand nucleic acid containing an X region and a Y region, wherein the 3'-terminal of the X region and the 5′-terminal of the Y region are linked via a linker region of a non-nucleotide structure, the X region contains a guide strand sequence of a mature miRNA, and the Y region contains a sequence completely complementary to the X region is an artificial match-type miRNA. The artificial match-type miRNA can suppress expression of the target gene.


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