The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2021
Filed:
Mar. 20, 2019
Applicants:
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Glattpark, CH;
Inventors:
Assignees:
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta GmbH, Glattpark, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/755 (2006.01); B01D 15/34 (2006.01); B01D 15/36 (2006.01); B01D 15/38 (2006.01); C07K 1/16 (2006.01); C07K 1/18 (2006.01); C07K 1/22 (2006.01); C07K 1/36 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); B01D 15/34 (2013.01); B01D 15/362 (2013.01); B01D 15/363 (2013.01); B01D 15/3809 (2013.01); C07K 1/16 (2013.01); C07K 1/18 (2013.01); C07K 1/22 (2013.01); C07K 1/36 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to a method for separating a mature von Willebrand Factor (mat-VWF) from von Willebrand Factor pro-peptide (VWF-PP) by incubating a composition comprising inducing dissociation of mat-VWF and VWF-PP by disruption of the non-covalently associated mat-VWF and VWF-PP, wherein said dissociation is induced by: (i) addition of at least one chelating agent, or (ii) increasing the pH to a pH of at least 7, and then collecting said mat-VWF to obtain a high purity, propeptide depleted mature VWF (mat-VWF).