The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2021
Filed:
Apr. 12, 2018
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Yangbing Zhao, Lumberton, NJ (US);
Xiaojun Liu, Wallingford, PA (US);
Wei Pan, Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61P 35/00 (2006.01); A61K 31/65 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 19/00 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 31/65 (2013.01); A61K 35/17 (2013.01); A61K 38/177 (2013.01); A61P 35/00 (2018.01); C07K 14/705 (2013.01); C07K 19/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.