The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2021
Filed:
Jun. 05, 2020
Barry P. Rosen, Boynton Beach, FL (US);
Stanislaw F. Wnuk, Miami, FL (US);
Masafumi Yoshinaga, Doral, FL (US);
MD Abu Hasan Howlader, Miami, FL (US);
SK MD Sazzad Hossain Suzol, Philadelphia, PA (US);
Barry P. Rosen, Boynton Beach, FL (US);
Stanislaw F. Wnuk, Miami, FL (US);
Masafumi Yoshinaga, Doral, FL (US);
Md Abu Hasan Howlader, Miami, FL (US);
Sk Md Sazzad Hossain Suzol, Philadelphia, PA (US);
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, Miami, FL (US);
Abstract
The subject invention provides methods and procedures for synthesis and/or semi-synthesis of the novel antibiotic arsinothricin (AST) and derivatives. Arsinothricin (AST), a new broad-spectrum organoarsenical antibiotic, is a non-proteinogenic analog of glutamate that effectively inhibits glutamine synthetase. The subject invention provides chemical synthesis of an intermediate in the pathway of AST synthesis, hydroxyarsinothricin (AST-OH), which can be converted to AST by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. The methods provide a source of the novel antibiotic that will be required for future clinical trials. The subject invention also provides AST derivatives as a new class of antibiotics.