The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2021
Filed:
Jun. 06, 2018
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Ashok Arasappan, Bridgewater, NJ (US);
Jason M. Cox, Whitehouse Station, NJ (US);
John S. Debenham, Scotch Plains, NJ (US);
Zhuyan Guo, Scotch Plains, NJ (US);
Jiafang He, Dayton, NJ (US);
Zahid Hussain, Dayton, NJ (US);
Zhong Lai, East Brunswick, NJ (US);
Derun Li, Scotch Plains, NJ (US);
Dongfang Meng, Morganville, NJ (US);
Subharekha Raghavan, Teaneck, NJ (US);
Sriram Tyagarajan, Edison, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention is directed to pyrazolopyrimidine compounds of the general structural formula I: which may be useful as therapeutic agents for the treatment of disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating cardiovascular and cerebrovascular diseases, such as hypertension, chronic kidney disease and heart failure, and neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.